minister, author, physician, dentist, and missionary, was born in Winton, North Carolina. His father, Lemuel Washington Boone (1827–1878), was a prominent minister and politician, and one of the original trustees of Shaw University.
Boone received his early education at Waters Normal and Industrial Institute in Winton. From 1896 to 1899 he attended Richmond Theological Seminary in Richmond, Virginia. In 1899, when the seminary merged with Wayland Seminary College of Meridian Hill in Washington, D.C., to form Virginia Union University and moved to its new Richmond campus at North Lombardy Street, Boone finished his senior year and became part of the university's first graduating class in 1900; he received the bachelor's of divinity degree.
During his final year at Virginia Union, Boone met Eva Roberta Coles from Charlottesville, Virginia, who studied at the neighboring African American women's institution, Hartshorn Memorial College, from which she graduated in 1899 ...