Isaac Myers was born in Baltimore, Maryland, the son of free African American parents, whose names and occupations are unknown. Myers was barred from public education, but he did attend a private day school run by a local clergyman. Leaving school at sixteen, he served an apprenticeship with a leading black ship caulker and then entered the trade himself, becoming by the age of twenty a supervisor, responsible for caulking some of Baltimore's largest clipper ships. During this period he married Emma V.; neither the precise year nor her full maiden name is known. They had three children, the first born in 1859.
Myers worked as a porter and shipping clerk for a wholesale grocer from 1860 to 1864 ran his own store for a year and then went back to ship caulking Soon after he returned to this trade however the city s white caulkers ...